Magdalena Götz studied Biology in Tübingen and Zürich, did her PhD-Thesis at the Friedrich Miescher Institute in Tübingen, Germany and her postdoctoral work with Jack Price at the NIMR London and Smith Kline Beecham Harlow on mechanisms of cerebral cortex development. She became a group leader at the Max-Planck Institute of Neurobiology in Martinsried, Germany she discovered the role of radial glial cells as neural stem cells and started direct neuronal reprogramming of glial cells using neurogenic fate determinants that she found to be critical in development and adult neurogenesis. As a director of the institute of stem cell research at the Helmholtz Center Munich and Chair of Physiological Genomics at the Ludwigs-Maximilians University Munich she extended her work to examine the role of different glial cells after brain injury in vivo in regenerative and non-regenerative models and further pioneered the field of direct neuronal reprogramming in vivo. She received many prizes and awards, such as the Gottfried-Wilhelm Leibniz Award, Schering Award and many more, is a member of EMBO and several Academies, Editorial Boards and Grant panels and since 2013 external member of the Max-Planck Society at the Max Planck Institute for Biochemistry in Martinsried.
10 selected publications:
Highlighted by Quadrato et al., Cell Stem Cell 18, 297-299.
Ninkovic J., Steiner-Mezzadri A., Jawerka M., Akinci U., Masserdotti G., Petricca S., Fischer J., von Holst A., Beckers J., Lie C.D., Petrik D., Miller E., Tang J., Wu J., Lefebvre V., Demmers J., Eisch A., Mezger D., Crabtree G., Irmler M., Poot R. and Götz M. (2013) The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell 13, 403-418. Highlighted by Faculty of 1000
Stahl R., Walcher T., De Juan Romeo C., Pilz G.A., Cappello S., Irmler M., Sanz Anquela J.M., Beckers J., Blum R., Borrell V. and Götz M. (2013) Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 153, 535-49. Highlighted by Nature, Science and Embo Journal.
Sirko S., Behrendt G., Johansson P., Tripathi P., Costa M., Bek S., Heinrich C., Tiedt S., Colak D., Dichgans M., Fischer I.R., Plesnila N., Staufenbiel M., Haass C., Snapyan M., Saghatelyan A., Tsai L.-H., Fischer A., Grobe K., Dimou L. and Götz M. (2013) Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. Cell Stem Cell 12, 426-439. Highlighted in Embo reports
Bardehle S., Krüger M., Schwausch J., Ninkovic J., Clevers H., Snippert H.J., Buggenthin F., Theis F.J., Meyer-Luehmann M., Bechmann I., Dimou L. and Götz M. (2013) Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature Neuroscience 16, 580-586. Highlighted in Embo reports
Beckervordersandforth R., Tripathi P., Ninkovic J., Bayam E., Lepier A., Stempfhuber B., Kirchhoff F., Hirrlinger J., Haslinger A., Chichung L. D., Beckers J., Yoder B., Irmler M. and Götz M. (2010) In vivo fate mapping and expression analysis reveals unique molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7, 744-58. Highlighted by Faculty of 1000
Hack M., Saghatelyan A., de Chevigny A., Lledo P.-M. and Götz M. (2005) Neuronal fate determinants of adult olfactory bulb neurogenesis. Nature Neuroscience 8, 865-872.
Heins N., Malatesta P., Cecconi F., Nakafuku M., Tucker K.L., Hack M.A., Chapouton P., Barde Y. and Götz M. (2002) Glial cells generate neurons: the role of the transcription factor Pax6. Nature Neuroscience 5, 308-315.
Malatesta P., Hartfuss E. and Götz M. (2000) Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development 127, 5253-5263.
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